Effect of Canarium Schweinfurthii (Africa Black Olive) Oil on Restraint Stressed Induced Renal Dysfunction in Wistar Rat

Abstract Background Chronic stress regardless of its origin has server repercussion on health, notably impacting the renal system. the kidney are vulnerable to prolonged stress, during stress the renal tissue are exposed to oxidative damage. This study aim to evaluate the protective effect of canarium schweinfurhii oil on renal dysfunction of Wistar rats subjected to restraint stress on the following biomarkers Creatinine, Urea, Blood urea nitrogen and Total protein respectively. Result A total of twenty-eight (28) apparently healthy adult male Wistar rat weighing between 150−170g were used for this study. They were allocated into four groups of seven rat (n = 7 rat/group). Group I: control group and administered with 10ml/kg/bw of water, Group II: stress group + 10ml/kg/bw of water, Group III: this group under goes stress and treated with 10ml/kg (1ml/100g) of canarium schweinfurhii oil, Group IV: this group under goes stress and treated with 20ml/kg (2ml/100g) of canarium schweinfurhii oil. All group were treated for 21 days. All data were expressed as mean ± SEM. The data obtained were statistically analyzed using analysis of variance (ANOVA) with Tukey’s multiple comparison post hoc tests to compare the level of significance between control and experimental groups. All statistical analysis were evaluated using SPSS version 17.0 software. The values of P < 0.05 were considered as significant. Conclusion The findings concluded canarium schweinfurhii oil at a dose of 10ml/kg (1ml/100g) provided some protection against stress-induced renal dysfunction