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Genome-wide analysis reveals prognostic value of novel signature CLU for malignant meningioma patients based on large-scale cohorts
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Background: Meningioma is one of the most common tumors of central
nervous system. Although genetic alterations have been linked to
elevated risk of malignancy for meningioma patients, the incongruence
between clinical outcomes and WHO grade classification still exist.
Therefore, large-scale genome-wide expression profiles identifying
reliable biomarkers remains incompletely investigated. Methods: In order
to identify genes related to invasion and metastasis process in
meningiomas, genome-wide profiles in 145 meningioma patients were
identified using microarray datasets GSE12530, GSE16581 and GSE43290
from the Gene Expression Synthesis (GEO) database based on differential
tissues expression. Protein-protein interaction (PPI) network were
constructed and functional annotations of DEGs were evaluated using R
software. In addition, differential expression and prognostic value of
CLU on meningioma was evaluated using immunohistochemistry in WHO grade
II-III meningioma from AHYMUN, a real-world cohort. Results: A total of
58 DEGs were significantly associated with malignant behaviours of
meningioma. Next, CLU were identified as hub gene in the PPI network,
showing markedly prognostic implications in 67 meningioma patients.
Expression level of CLU significantly climbed with elevated WHO risk
classification. Interestingly, 40 genes were screened according to
differential CLU expression. Additionally, significant high expression
level of CLU were found in meningiomas tissue than normal tissues,
predicting significant poor prognosis for 100 meningiomas patients from
AHYMUN cohort. Conclusion: In conclusion, this study first reveals novel
role of CLU using genome-wide expression profiles in high-risk WHO grade
of meningioma and significant prognostic value based on large-scale
cohorts. This work laid the foundation for the targeted molecular
therapies and provided new insights into the treatment and prognostic
srategies of meningiomas.
Title: Genome-wide analysis reveals prognostic value of novel signature CLU for malignant meningioma patients based on large-scale cohorts
Description:
Background: Meningioma is one of the most common tumors of central
nervous system.
Although genetic alterations have been linked to
elevated risk of malignancy for meningioma patients, the incongruence
between clinical outcomes and WHO grade classification still exist.
Therefore, large-scale genome-wide expression profiles identifying
reliable biomarkers remains incompletely investigated.
Methods: In order
to identify genes related to invasion and metastasis process in
meningiomas, genome-wide profiles in 145 meningioma patients were
identified using microarray datasets GSE12530, GSE16581 and GSE43290
from the Gene Expression Synthesis (GEO) database based on differential
tissues expression.
Protein-protein interaction (PPI) network were
constructed and functional annotations of DEGs were evaluated using R
software.
In addition, differential expression and prognostic value of
CLU on meningioma was evaluated using immunohistochemistry in WHO grade
II-III meningioma from AHYMUN, a real-world cohort.
Results: A total of
58 DEGs were significantly associated with malignant behaviours of
meningioma.
Next, CLU were identified as hub gene in the PPI network,
showing markedly prognostic implications in 67 meningioma patients.
Expression level of CLU significantly climbed with elevated WHO risk
classification.
Interestingly, 40 genes were screened according to
differential CLU expression.
Additionally, significant high expression
level of CLU were found in meningiomas tissue than normal tissues,
predicting significant poor prognosis for 100 meningiomas patients from
AHYMUN cohort.
Conclusion: In conclusion, this study first reveals novel
role of CLU using genome-wide expression profiles in high-risk WHO grade
of meningioma and significant prognostic value based on large-scale
cohorts.
This work laid the foundation for the targeted molecular
therapies and provided new insights into the treatment and prognostic
srategies of meningiomas.
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