Correlation of Prostate Volume with Age, Serum Prostate-Specific Antigen, and Symptom Severity in Men with Prostatic Enlargement in DELSUTH, Oghara

Abstract Background: Benign prostatic hyperplasia (BPH) is a major cause of lower urinary tract symptoms (LUTS) in ageing men. Prostate volume (PV), serum prostate-specific antigen (PSA), and symptom severity assessed by the International Prostate Symptom Score (IPSS) are central to evaluation, yet their interrelationships remain inconsistent across populations. Methods: The aim of this study was to evaluate the correlation between prostate volume, age, serum PSA, and symptom severity among men with prostatic enlargement. A cross-sectional study was conducted among 72 men aged ≥ 40 years presenting with LUTS at DELSUTH, Oghara. PV was measured using transrectal ultrasonography (TRUS), PSA obtained from records, and symptom severity assessed using IPSS. Pearson’s correlation and multivariate regression analyses were performed. Results: Mean age was 67.3 ± 10.5 years. Mean PV was 106.7 ± 71.2 mL, PSA 8.1 ± 7.7 ng/mL, and IPSS 23.3 ± 5.4. PV correlated significantly with age (r = 0.366, p = 0.002) and IPSS (r = 0.393, p = 0.001), but not with PSA (r = 0.128, p = 0.284). PSA showed weak correlation with IPSS (r = 0.256, p = 0.030). Regression analysis identified age and IPSS as independent predictors of PV. Conclusion: Prostate volume is more strongly associated with symptom severity and age than PSA. TRUS-derived PV remains a more reliable clinical indicator than PSA in symptomatic men.