FORMULATION AND EVALUATION NANOSPONGE BASED ANTIFUNGAL GEL CONTAINING FLUCONAZOLE

The primary aim of this study is to develop nanosponges of fluconazole intendedfor topical application in gel form. The successful formulation of nanosponges wasachieved using ethyl cellulose and eudragit RS100 as polymers, polyvinyl acetateas the surfactant, and dichloromethane as the solvent through the emulsion solventdiffusion technique. The resulting nanosponges were incorporated into a topical gelusing agents such as Carbopol 934 and HPMC K4M. The prepared nanospongesand gel underwent various evaluations, including production yield, drug entrapmentefficiency, FTIR, DSC, SEM, spreadability, pH, viscosity, and in-vitro drug release.Among the different formulations of nanosponges, those created with ethylcellulose exhibited favorable properties and were subsequently transformed into gelform. The resulting gel demonstrated drug release for a duration of up to 12 hours.In summary, the emulsion solvent diffusion method proved to be an effectiveapproach for the formulation of nanosponges.