Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Isotretinoin induced achilles tendinopathy: Histopathological and biomechanical evaluation on rats
View through CrossRef
Abstract
Objective
The aim of the present study was to evaluate histopathological and biomechanical effects of isotretinoin on Achilles tendon.
Materials & methods
Sixteen rats were divided into two groups including the control group (n = 8) and isotretinoin group (n = 8). The control group received 1.42 ml/kg soy oil per day whereas the isotretinoin group received 15 mg/kg/day (gavage dose 1.42 ml/kg) isotretinoin dissolved in soy oil through gavage method for 6 weeks. Achilles tendons were excised at the end of week 6. The tendon samples were evaluated by hematoxylin-eosin under a light microscope. Quantitative evaluation was performed via Movin and Bonar scoring. A computer-monitored tensile testing machine was utilised for biomechanical testing. Biomechanical characteristics of the tendon samples (elastic modulus, yield force, ultimate tensile force) were measured.
Results
Histopathological evaluation revealed a significantly higher Movin and Bonar scores in histopathological evaluation. Movin score in isotretinoin group was 4.1 ± 2.5 and it was 2.3 ± 1.0 in control group (p = 0.032). Bonar score in isotretinoin group was 2.9 ± 1.4 and it was 1.6 ± 0.7 in control group (p = 0.022). In line with histopathological evaluation, biomechanical measurements in isotretinoin group (elastic modulus, yield force, ultimate tensile force) were significantly lower than the control group. Elastic modulus in isotretinoin group was 227 ± 27.7 N/mm2 and in control group it was 281.7 ± 38.7 N/mm2 (p = 0.006). In isotretinoin group; yield force was 33.7 ± 4.3 Pa and in control group it was 40.8 ± 5.9 Pa (p = 0.021). Ultimate tensile force in isotretinoin group was 35.7 ± 4.2 Pa and in control group it was 44 ± 7 Pa (p = 0.009).
Conclusion
The present study detected histopathological and biomechanical negative effect of isotretinoin on Achilles tendon. Therefore, isotretinoin should be questioned in medical history of patients with tendinopathy.
ER -
Title: Isotretinoin induced achilles tendinopathy: Histopathological and biomechanical evaluation on rats
Description:
Abstract
Objective
The aim of the present study was to evaluate histopathological and biomechanical effects of isotretinoin on Achilles tendon.
Materials & methods
Sixteen rats were divided into two groups including the control group (n = 8) and isotretinoin group (n = 8).
The control group received 1.
42 ml/kg soy oil per day whereas the isotretinoin group received 15 mg/kg/day (gavage dose 1.
42 ml/kg) isotretinoin dissolved in soy oil through gavage method for 6 weeks.
Achilles tendons were excised at the end of week 6.
The tendon samples were evaluated by hematoxylin-eosin under a light microscope.
Quantitative evaluation was performed via Movin and Bonar scoring.
A computer-monitored tensile testing machine was utilised for biomechanical testing.
Biomechanical characteristics of the tendon samples (elastic modulus, yield force, ultimate tensile force) were measured.
Results
Histopathological evaluation revealed a significantly higher Movin and Bonar scores in histopathological evaluation.
Movin score in isotretinoin group was 4.
1 ± 2.
5 and it was 2.
3 ± 1.
0 in control group (p = 0.
032).
Bonar score in isotretinoin group was 2.
9 ± 1.
4 and it was 1.
6 ± 0.
7 in control group (p = 0.
022).
In line with histopathological evaluation, biomechanical measurements in isotretinoin group (elastic modulus, yield force, ultimate tensile force) were significantly lower than the control group.
Elastic modulus in isotretinoin group was 227 ± 27.
7 N/mm2 and in control group it was 281.
7 ± 38.
7 N/mm2 (p = 0.
006).
In isotretinoin group; yield force was 33.
7 ± 4.
3 Pa and in control group it was 40.
8 ± 5.
9 Pa (p = 0.
021).
Ultimate tensile force in isotretinoin group was 35.
7 ± 4.
2 Pa and in control group it was 44 ± 7 Pa (p = 0.
009).
Conclusion
The present study detected histopathological and biomechanical negative effect of isotretinoin on Achilles tendon.
Therefore, isotretinoin should be questioned in medical history of patients with tendinopathy.
ER -.
Related Results
Isotretinoin-Induced Hematuria in Acne Patients: Frequency, Risk Factors, and Management Recommendations from a Single-Center Study
Isotretinoin-Induced Hematuria in Acne Patients: Frequency, Risk Factors, and Management Recommendations from a Single-Center Study
Introduction: Isotretinoin-induced hematuria is very rare; it has been reported in one study and individual case reports but never proven statistically. Objectives: To determine wh...
Reduced intra-tendinous sliding in Achilles tendinopathy during active plantarflexion regardless of horizontal foot position
Reduced intra-tendinous sliding in Achilles tendinopathy during active plantarflexion regardless of horizontal foot position
ABSTRACTThe Achilles tendon consists of three subtendons with the ability to slide relative to each other. As optimal intra-tendinous sliding is thought to reduce the overall stres...
Association of Achilles Tendinitis and Tendinopathy with Knee Osteoarthritis among Older Adults
Association of Achilles Tendinitis and Tendinopathy with Knee Osteoarthritis among Older Adults
Background: Achilles tendon is a band of connective tissue, in some cases due to overuse activity, tendon may inflame which causes pain and irritation. Achilles tendinitis and tend...
Expressions of thyroid and growth hormones as risk factors for Achilles tendinopathy in a population of Nigerian football players: A preliminary study
Expressions of thyroid and growth hormones as risk factors for Achilles tendinopathy in a population of Nigerian football players: A preliminary study
Background: Achilles Tendinopathy (AT) has become a global concern in Sports Medicine especially as it results in interruption of the athletes’ career. Several intrinsic and extrin...
Laser-Engineered Retinoid Nanocarriers Mitigate Isotretinoin-Induced Hepatic Injury: A Multilevel Hematological, Physiological, Molecular, and Histopathological Study in Rats
Laser-Engineered Retinoid Nanocarriers Mitigate Isotretinoin-Induced Hepatic Injury: A Multilevel Hematological, Physiological, Molecular, and Histopathological Study in Rats
Isotretinoin is an effective retinoid that is used as a treatment for severe acne, but its implementation is limited due to systemic adverse events, especially hepatotoxicity, whic...
Isotretinoin update
Isotretinoin update
AbstractBackgroundAcne is a common, chronic inflammatory condition seen in nearly all teenagers and many adult females, with a global lifetime prevalence between 70‐85%. While a ma...
Penggunaan Isotretinoin Oral pada Tatalaksana Akne Vulgaris
Penggunaan Isotretinoin Oral pada Tatalaksana Akne Vulgaris
<p>Akne vulgaris adalah penyakit kulit paling umum dan dikaitkan dengan kecemasan, penurunan harga diri, stigma, dan skar pada wajah yang dapat menjadi beban penyakit yang si...
Isotretinoin Use during Chemical Skin Resurfacing: A Review of Complications
Isotretinoin Use during Chemical Skin Resurfacing: A Review of Complications
Introduction:
There is a great deal of concern when it comes to resurfacing the skin of patients who have recently taken or are taking isotretinoin. Much of the...