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In vitro Cytotoxic and Thrombolytic Activity of Methanolic Extract of Bauhinia acuminata Leaves
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The present study was designed to investigate the cytotoxic and thrombolytic activity. Methanolic extract of leaves of B. acuminate was assessed with the Brine shrimp lethality bioassay used to evaluate cytotoxicity. The methanolic extract of B. acuminata was assessed with human blood to evaluate thrombolytic effect. The extract showed remarkable cytotoxic activity, LC50 value of the extract was 15.41μg/ml compared to vincristin sulphate. It also evaluated for thrombolytic agent compared to streptokinase. It has the significant thrombolytic effect which was about 10.058%. These findings demonstrate that the leaves extract of B. acuminata have significance cytotoxic and thrombolytic activities. This plant can be used in further investigation for lead compound isolation and other pharmacological activities.
UK Journal of Pharmaceutical and Biosciences
Title: In vitro Cytotoxic and Thrombolytic Activity of Methanolic Extract of Bauhinia acuminata Leaves
Description:
The present study was designed to investigate the cytotoxic and thrombolytic activity.
Methanolic extract of leaves of B.
acuminate was assessed with the Brine shrimp lethality bioassay used to evaluate cytotoxicity.
The methanolic extract of B.
acuminata was assessed with human blood to evaluate thrombolytic effect.
The extract showed remarkable cytotoxic activity, LC50 value of the extract was 15.
41μg/ml compared to vincristin sulphate.
It also evaluated for thrombolytic agent compared to streptokinase.
It has the significant thrombolytic effect which was about 10.
058%.
These findings demonstrate that the leaves extract of B.
acuminata have significance cytotoxic and thrombolytic activities.
This plant can be used in further investigation for lead compound isolation and other pharmacological activities.
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