Temperament gene inheritance

This article is published in Elsevier Meta Gene in September 2020 https://doi.org/10.1016/j.mgene.2020.100728 A temperament gene and its inheritance mechanisms have never been academically addressed. In this study we have tried to explain a genetic basis of a temperament inheritance mode; temperament is regularly inherited by the son from the mother and by the daughter from the father. Such a transmission mode corresponds to the X chromosome-linked inheritance and indicates that a temperament gene locus is on the X chromosome. Here we show that most probable temperament gene candidate is the VAMP7 gene of Xq PAR; besides its role in neuritogenesis, a relationship was proposed between the outward migration mode of the VAMP7 mediated vesicles, the female paternal temperament allele preservation in the secondary oocyte/ovum, and its transmission to the next generation. We have eliminated 113 temperament gene candidates in the distal Xq region, due to their mRNA numbers, expression in the brain and ovary, accordance to our proposed inheritance mode of a silent temperament allele, and genetic linkages.