Serum albumin predicts hyperuricemia in patients with idiopathic membranous nephropathy

Abstract Aim: The aim of the study was to examine the crosss-ectional association between serum albumin and hyperuricemia (HU).Subjects and methods: HU was defined as uric acid ≥420 mol/L for the male population and ≥357 mol/L for the female population.We reviewed the files of 216 consecutive patients with Idiopathic membranous nephropathy treated at our hospital between 2010 and 2019.The correlation of serum albumin with hyperuricemia and the association between serum uric acid levels and the clinical of Idiopathic membranous nephropathy were assessed by statistical analysis.A multivariable logistic analysis model was applied to test the association after adjusting for a number of potential confounding factors.Results: Triglyceride and serum albumin were higher in group with hyperuricemia than in group without hyperuricemia(p=0.020, P<0.001 respectively). As serum albumin rose for 1 g/L the probability for hyperuricemia increased for 17 % (adjusted II OR= 1.17, 95%CI (1.02, 1.35), P = 0.0294). A unit increase in serum albumin was associated with increases of 6.64 umol/L in uric acid (adjusted II β = 6.64, P = 0.0135). Using Tertile 1(T1) for reference, Tertile 3 (T3) group was positively associated with both hyperuricemia (adjusted II OR=44.21, 95%CI(12.76, 75.67), P=0.0064) and uric acid (adjusted II β=98.64, P=0.0116). The interaction test showed signifcant interactions between serum albumin and BMI when hyperuricemia or uric acid were used to determine the outcomes. The participants BMI ≥25 kg/m2 had a higher OR between serum albumin and hyperuricemia and had a higher β between serum albumin and uric acid than BMI＜25kg/m2 (for hyperuricemia: OR =1.01 vs 1.18, P for interaction=0.0056; for uric acid: β =0.96 vs 6.23, P for interaction =0.0154). The area under the ROC curve (AUC) was 0.7615 in the participants BMI ≥25 kg/m2. The sensitivity and specifcity of this point were 47.37% and 95.83%,respectively.Conclusion: Our study showed that serum albumin was positively associated with hyperuricemia and uric acid, especially in obese subjects.