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Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review
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Background:
Phthalates are widely used in the plastics industry. Di-2-Ethylhexyl Phthalate
(DEHP) is one of the most important phthalate metabolites that disrupt the function of endocrine
glands. Exposure to DEHP causes numerous effects on animals, humans, and the environment. Low
doses of DEHP increase neurotoxicity in the nervous system that has arisen deep concerns due to the
widespread nature of DEHP exposure and its high absorption during brain development.
Objective:
In this review article, we evaluated the impacts of DEHP exposure from birth to adulthood
on neurobehavioral damages. Then, the possible mechanisms of DEHP-induced neurobehavioral
impairment were discussed.
Methodology:
Peer-reviewed articles were extracted through Embase, PubMed, and Google Scholar
till the year 2021.
Results:
The results showed that exposure to DEHP during pregnancy and infancy leads to memory
loss and irreversible nervous system damage.
Conclusion:
Overall, it seems that increased levels of oxidative stress and inflammatory mediators
possess a pivotal role in DEHP-induced neurobehavioral impairment.
Bentham Science Publishers Ltd.
Title: Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions:
A Narrative Review
Description:
Background:
Phthalates are widely used in the plastics industry.
Di-2-Ethylhexyl Phthalate
(DEHP) is one of the most important phthalate metabolites that disrupt the function of endocrine
glands.
Exposure to DEHP causes numerous effects on animals, humans, and the environment.
Low
doses of DEHP increase neurotoxicity in the nervous system that has arisen deep concerns due to the
widespread nature of DEHP exposure and its high absorption during brain development.
Objective:
In this review article, we evaluated the impacts of DEHP exposure from birth to adulthood
on neurobehavioral damages.
Then, the possible mechanisms of DEHP-induced neurobehavioral
impairment were discussed.
Methodology:
Peer-reviewed articles were extracted through Embase, PubMed, and Google Scholar
till the year 2021.
Results:
The results showed that exposure to DEHP during pregnancy and infancy leads to memory
loss and irreversible nervous system damage.
Conclusion:
Overall, it seems that increased levels of oxidative stress and inflammatory mediators
possess a pivotal role in DEHP-induced neurobehavioral impairment.
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