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A Novel Fluorescent Probe Based on Perylene Derivative for Hg 2+ Ions and Biological Thiols and its Application in Live Cell Imaging and Theoretical Calculations
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Abstract
The selective and sensitive detection of biothiols; cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) in aqueous solutions is of considerable importance because of their pivotal roles in maintaining the reducing environment in the cells. This study describes a strategy for the determination of biothiols based on the PDI/Met‐Hg
2+
complex platform. We designed and fabricated methionine modified perylene diimide molecule as a selective sensing probe for Hg
2+
ions in aqueous solutions (
PDI/Met‐Hg
2+
). The complex between perylene bisimide derivative (
PDI/Met)
and Hg
2+
was investigated and it demonstrated turn‐on fluorescence response for the detection of the biological thiols. Besides,
PDI/Met
displayed fluorescence quenching response in the presence of mercury ions and the emission intensity of
PDI/Met‐Hg
2+
was recovered after transferring biothiols (Cys, Hcy, and GSH). Thus,
PDI/Met
could be utilized as a fluorescent chemosensor for the sequential recognition of mercury ions and biological thiols.
Title: A Novel Fluorescent Probe Based on Perylene Derivative for Hg
2+
Ions and Biological Thiols and its Application in Live Cell Imaging and Theoretical Calculations
Description:
Abstract
The selective and sensitive detection of biothiols; cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) in aqueous solutions is of considerable importance because of their pivotal roles in maintaining the reducing environment in the cells.
This study describes a strategy for the determination of biothiols based on the PDI/Met‐Hg
2+
complex platform.
We designed and fabricated methionine modified perylene diimide molecule as a selective sensing probe for Hg
2+
ions in aqueous solutions (
PDI/Met‐Hg
2+
).
The complex between perylene bisimide derivative (
PDI/Met)
and Hg
2+
was investigated and it demonstrated turn‐on fluorescence response for the detection of the biological thiols.
Besides,
PDI/Met
displayed fluorescence quenching response in the presence of mercury ions and the emission intensity of
PDI/Met‐Hg
2+
was recovered after transferring biothiols (Cys, Hcy, and GSH).
Thus,
PDI/Met
could be utilized as a fluorescent chemosensor for the sequential recognition of mercury ions and biological thiols.
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