Personalised Medicine Implementation into Healthcare: A Multistakeholder Approach for Translating Innovation into Clinical Practice Christine Hasenauer¹

Background Personalised medicine has evolved from a largely research-driven concept into an increasingly important component of modern healthcare. Advances in genomics, molecular diagnostics, bioinformatics, artificial intelligence, and digital health technologies have enabled more precise approaches to disease prevention, diagnosis, and treatment. Despite considerable scientific progress, however, the implementation of personalised medicine within routine clinical practice remains uneven across Europe. Objective This article examines the principal barriers to implementing personalised medicine within healthcare systems and explores how coordinated multistakeholder collaboration can facilitate the translation of scientific innovation into everyday clinical care. Discussion Successful implementation of personalised medicine extends beyond technological innovation. It requires coordinated engagement of healthcare professionals, patients, citizens, medical societies, healthcare providers, researchers, regulators, and policymakers. Drawing upon the experience of the European Partnership for Personalised Medicine (EP PerMed), five complementary areas are identified as central to implementation: professional education, patient engagement, public health literacy, collaboration with medical societies, and cooperation between healthcare providers. Together, these domains create an integrated framework capable of supporting sustainable implementation across European healthcare systems. Conclusions The future of personalised medicine depends not only on scientific discovery but also on coordinated implementation strategies that integrate education, collaboration, governance, and public engagement. Multistakeholder partnerships provide an effective mechanism for translating innovation into equitable and sustainable healthcare across Europe. Keywords