Multicomponent synthesis of heterocyclic compounds

Rapid and efficient, multicomponent domino reactions (MDRs) are a useful tool for the one-pot synthesis of flexible heterocycles with diverse and complicated structures. Reduced chemical waste, lower starting-material prices, and lower energy and labour requirements are all possible thanks to these reactions. Additionally, the time required for a response may be greatly reduced. The most up-to-date research on multicomponent domino reactions for constructing heterocyclic skeletons with five, six, or seven members, as well as their multicyclic derivatives, is discussed in this Review. In recent years, our group has developed innovative procedures based on the transition-metal-mediated intramolecular addition reaction of heteronucleophiles and stabilised carbon nucleophiles to inactivated alkenes and alkynes. We provide a brief overview of many recent synthetic uses of these novel methods in this paper. Multicomponent reactions involving Pd-mediated intramolecular cyclization followed by carbon-carbon bond formation are the focus here.