Copeptin: a novel marker for diagnosis and prognosisof various diseases associated with diabetes

Copeptin is an arginine vasopressin (AVP) precursor whose C-terminal has evolved into 39 amino acids. This AVPprecursor is converted into equimolar amounts of copeptin, neurophysin II, and AVP. A strong connection betweenthe release of AVP and copeptin was observed. Measurement of AVP concentration remains complicated sinceAVP is an unstable peptide and, additionally, it is bound by platelets. Copeptin remains stable in serum or plasmafor several days in a warm environment and testing for copeptin yields findings in 1 h. Consequently, the quantityof copeptin might serve as a perfect replacement for reflecting the level of AVP. Copeptin has become identifiedas a beneficial measure in various diseases. The physiology and structure of copeptin, as well as its potential, toact as a predictive and diagnostic indicator of different diseases associated with diabetes, are the goals of thecurrent review.