Journal of Modern Thermodynamics in Mechanical System

Surface thermodynamics study is the application of colloidal science to an investigative search for the nature and rate of heat transfer on the surface of any particle-particle interaction. This paper presents the theory and a designed practical methodology for the demonstration of the Combined Hamaker Coefficient. The nature and effectiveness of any interaction between two or more particles can be determined using this thermodynamic approach. Samples of blood lymphocytes and HIV particles in a serum containing antiretroviral drug particles were used. The Hamaker concept based on Van der Waal’s theory for surface energy of attraction and repulsion can be demonstrated. The interfacial work done by particles can be investigated during their combined interaction in an in-vivo experiment. The data obtained can prove that the combined Hamaker coefficient when negative is responsible for particle-particle repulsion and positive for particle-particle attraction. This implies the repulsion of the viral particle in lymphocytes and drug particles in the intervening serum. The overall change in the energy potential of all particle matter is revealed to be a concurrent area of surface thermodynamics that employs mathematical concepts and software in the designing and formulation of drugs for the management of viral infections.