The role of oncogenic viruses in the etiopathogenesis of oral squamous cell carcinoma – literature review

The most common kind of oral cancer is known to be the epithelial cells cancer. The disease develops under the influence of many factors. Extensive studies confirms relationship of the occurrence of cancer in the mouth area and infection with oncogenic virus. Papilloma virus (HPV) and Ebstein-Barr (EBV) are considerate to be the most potent oncogenic viruses. Aim. The aim of the studies was to present the role of the oncogenic virus in the development of squamous cell of oral cancer. Materials and methods. Literature was carried out from November 2014 to January 2018 period using „Pub-Med”, MEDLINE, SCOPUS with keywords: squamous cell carcinoma of the Oral Cavity, oncogenic factors in squamous cell in oral carcinoma, oncogenic virus, role of Ebstein-Barr virus in the development of squamous cell of oral carcinoma, role of human papillomavirus in the development of squamous cell carcinoma. Results. To the review 16 publications were qualified that meet certain criteria for good literature. Identification of comparative characteristics was aimed at finding a common denominator of research results. Discussion. In the review the focus point was on the role of factors which is oncogenic virus. Analysis of the available data has confirmed that more and more frequent cause of commonly known factors such as tobacco smoke, alcohol, neglect hygiene, and genetic factor became undoubtedly the role of virus factor. Summary. High incidence of cancers has led to the search for relevant etiological factors in the development carcinoma process, especially in and around oral cavity. Knowledge of the most cancerogenic factors is important in order to prevent, and the search of effective treatments. In addition, the cited publications, draws attention to the fact the use of saliva as research material. This throws a new light on the work of dentists and the possibility of their involvement in the process of tumor detection and the initiating factor of oncogenesis.