Familial Eruptive Syringoma: A Case Report of Recurrent Papular Eruption Misdiagnosed as Plane Warts

One of the rare benign adnexal tumors of eccrine origin is familial eruptive syringoma that may closely resemble common dermatologic conditions such as plane warts or lichen nitidus, leading to repeated misdiagnosis and unnecessary treatment. This case study describes two sisters who presented with widespread flesh-colored, flat-topped, symmetrical papules that gradually increased in number over the trunk and upper limbs. The lesions had been previously treated as plane warts with laser therapy, resulting in rapid recurrence. Dermoscopic examination revealed uniform light-brown papules with fine reticular pigment network, while histopathology demonstrated eccrine ducts lined by two layers of cuboidal epithelial cells forming characteristic comma- and tadpole-shaped structures embedded in a fibrous stroma, confirming the diagnosis of syringoma. The patients were reassured of the benign nature of the disease and advised to discontinue destructive procedures. Follow-up after three months revealed stable lesions with no new eruptions. This case highlights the importance of considering familial eruptive syringoma in the differential diagnosis of symmetrical papular eruptions, especially in young females, and underscores the value of biopsy confirmation to avoid unnecessary interventions.