SYNTHESIS AND TOXICOLOGICAL BIOASSAY OF ARYLAMIDOXIMES

Amidoximes are a class of organic compounds that present a wide variety of technological, biological and pharmacological applications. Currently, there are several methodologies aimed at the preparation of these compounds, however, some toxicological studies of structurally simple arylamidoximes remain unexplored. Therefore, the objective of this work was to perform the synthesis and toxicological bioassay of different arylamidoximes against Artemia saline Leach. The arylamidoximes were synthesized from the reaction between different arylnitriles and hydroxylamine hydrochloride in hydroethanolic medium and characterized by melting point, IR, 1H NMR, and 13C NMR. Toxicological bioassay of the arylamidoximes was carried out using Artemia saline Leach and the LC50 was determined using the POLO-PC software. As a result, the arylamidoximes were obtained in reaction times ranging from 15 to 45 minutes and in good yields (55 to 91%). The toxicological bioassay indicated that all arylamidoximes tested showed toxicity ranging from high to moderate with LC50 from 18.553 to 273.313 μg/mL. In addition, the best activity was observed for the arylamidoximes containing the methyl group in the meta position. In short, the toxicological activity found for arylamidoximes reinforces the pharmacological potential of these compounds and may motivate researchers to promote structural modifications in these compounds in order to make them future drugs.