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Effect of Cadmium Exposure on Zinc Levels in Normal Non-Diabetic and Diabetic Rats Induced by Streptozotocin
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Diabetic rats induced by streptozotocin and normal non-diabetic rats were exposed to cadmiumsulphate in drinking water at a dose of 200 mg / L for 30 days. At the end of the exposure, theblood, kidney and pancreas of each rat were taken for the determination of cadmium and zinc.The results show a significant increase in the level of cadmium in the blood, kidney andpancreas of normal non-diabetic rats and diabetic rats compared to the control group. Thecadmium concentration was significantly higher in plasma and tissues in diabetic rats comparedto normal non-diabetic rats. Cadmium poisoning resulted in a significant decrease in the levelof zinc in the blood and tissues of normal non-diabetic rats and diabetic rats compared to theirrespective controls. This study reveals that diabetic rats induced by streptozotocin are moresensitive to the toxic effects of cadmium than normal rats.Key words: Cadmium, zinc, plasma, pancreas, kidneys, diabetes
Title: Effect of Cadmium Exposure on Zinc Levels in Normal Non-Diabetic and Diabetic Rats Induced by Streptozotocin
Description:
Diabetic rats induced by streptozotocin and normal non-diabetic rats were exposed to cadmiumsulphate in drinking water at a dose of 200 mg / L for 30 days.
At the end of the exposure, theblood, kidney and pancreas of each rat were taken for the determination of cadmium and zinc.
The results show a significant increase in the level of cadmium in the blood, kidney andpancreas of normal non-diabetic rats and diabetic rats compared to the control group.
Thecadmium concentration was significantly higher in plasma and tissues in diabetic rats comparedto normal non-diabetic rats.
Cadmium poisoning resulted in a significant decrease in the levelof zinc in the blood and tissues of normal non-diabetic rats and diabetic rats compared to theirrespective controls.
This study reveals that diabetic rats induced by streptozotocin are moresensitive to the toxic effects of cadmium than normal rats.
Key words: Cadmium, zinc, plasma, pancreas, kidneys, diabetes.
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