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Supplemental Figure 3 dNICD in Brat-RNAi brain localizes in nucleus. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
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<p>(A) Cytosolic extraction of brat-RNAi (bratIR) Drosophila brains shows higher levels of NICD compared to the control brain. (B) Nuclear extract also shows higher NICD in brat-RNAi compared to control suggesting increased NICD nuclear transport. (C) Densitometric quantification of nuclear NICD.</p>
American Association for Cancer Research (AACR)
Title: Supplemental Figure 3 dNICD in Brat-RNAi brain localizes in nucleus. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Description:
<p>(A) Cytosolic extraction of brat-RNAi (bratIR) Drosophila brains shows higher levels of NICD compared to the control brain.
(B) Nuclear extract also shows higher NICD in brat-RNAi compared to control suggesting increased NICD nuclear transport.
(C) Densitometric quantification of nuclear NICD.
</p>.
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Data from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Data from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
<div>Abstract<p>Cancer stem cells exert enormous influence on neoplastic behavior, in part by governing asymmetric cell division and the balance between self-renewal an...
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Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Drosophila
Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Abstract
Cancer stem cells exert enormous influence on neoplastic behavior, in part by governing asymmetric cell division and the balance between self-renewal and...
Data from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Data from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
<div>Abstract<p>Cancer stem cells exert enormous influence on neoplastic behavior, in part by governing asymmetric cell division and the balance between self-renewal an...
Supplemental Figure 1 Brat protein expression is reduced in inscuteable driven brat RNAi neuroblasts at larval and adult stages. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenes
Supplemental Figure 1 Brat protein expression is reduced in inscuteable driven brat RNAi neuroblasts at larval and adult stages. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenes
<p>(A-H) Panels showing 3rd Inster larval brain. (A-D) Brain of normal larva expressing Brat protein. (E-H) Brain of brat-RNAi expressing larva showing reduced Brat protein. ...
Supplemental Figure 1 Brat protein expression is reduced in inscuteable driven brat RNAi neuroblasts at larval and adult stages. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenes
Supplemental Figure 1 Brat protein expression is reduced in inscuteable driven brat RNAi neuroblasts at larval and adult stages. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenes
<p>(A-H) Panels showing 3rd Inster larval brain. (A-D) Brain of normal larva expressing Brat protein. (E-H) Brain of brat-RNAi expressing larva showing reduced Brat protein. ...
Brain Organoids, the Path Forward?
Brain Organoids, the Path Forward?
Photo by Maxim Berg on Unsplash
INTRODUCTION
The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique. Advancements ...
Supplemental Figure 3 dNICD in Brat-RNAi brain localizes in nucleus. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Supplemental Figure 3 dNICD in Brat-RNAi brain localizes in nucleus. from <i>Drosophila</i> Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
<p>(A) Cytosolic extraction of brat-RNAi (bratIR) Drosophila brains shows higher levels of NICD compared to the control brain. (B) Nuclear extract also shows higher NICD in b...