CROHN DISEASE: Patofisiologi, Diagnosis, dan Penatalaksanaan

ABSTRAK Penyakit Crohn adalah kondisi radang usus idiopatik kronis, ditandai dengan lesi, yang dapat memengaruhi seluruh saluran cerna mulai dari mulut hingga anus. Insiden tahunan penyakit crohn mencapai 3 hingga 20 kasus per 100.000 dengan usia rata-rata 30 tahun. Patofisiologi penyakit crohn didasarkan pada peradangan jaringan oleh respons imun yang tidak dapat dikendalikan terhadap antigen bakteri. Penegakan diagnosis dengan Computed tomography (CT), magnetic resonance imaging (MRI), dan ultrasonografi menjadi standar diagnosis dari penyakit crohn. Prognosis dari penyakit crohn ini tergantung dari komplikasi yang muncul seperti fistula dan bowel obstruction usus serta kondisi remisi dari pasien, ataupun tingkat respon tiap pasien terhadap pengobatan sehingga dalam menangani penyakit crohn adalah mengobati kondisi peradangan aktif hingga cepat mengalami remisi dan mempertahankannya selama mungkin. Kata Kunci: crohn disease; patofisiologi; diagnosis; penatalaksanaan; prognosis   ABSTRACT Crohn's disease is a chronic idiopathic inflammatory bowel condition, characterized by lesions, which can affect the entire gastrointestinal tract from the mouth to the anus. The annual incidence of Crohn's disease is 3 to 20 cases per 100,000 with a median age of 30 years. The pathophysiology of Crohn's disease is based on tissue inflammation by an uncontrollable immune response to bacterial antigens. Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography have become the standard for the diagnosis of Crohn's disease. The prognosis of Crohn's disease depends on complications such as enteric fistula and intestinal neoplasia and the condition of remission of the patient, or the level of response of each patient to treatment so that in treating Crohn's disease is to treat the active inflammatory condition until it goes into remission quickly and maintain it as long as possible. Keyword: crohn disease; pathophysiology; diagnosis; treatment; prognosis