Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
A VIEW OF SUR/KIR6.X, KATP CHANNELS
View through CrossRef
▪ Abstract ATP-sensitive potassium channels, termed KATP channels, link the electrical activity of cell membranes to cellular metabolism. These channels are heteromultimers of sulfonylurea receptor (SUR) and KIR6.x subunits associated with a 1:1 stoichiometry as a tetramer (SUR/KIR6.x)4. KIR6.x forms the pores, whereas SUR regulates their activity. Changes in [ATP]i and [ADP]i gate the channel. The diversity of KATP channels results from the assembly of SUR and KIR6.x subtypes. KIR6.1-based channels differ from KIR6.2 channels mainly by their smaller unitary conductance. SUR1- and SUR2-based channels are distinguished by their differential sensitivity to sulfonylureas, whereas SUR2A-based channels are distinguished from SUR2B channels by their differential sensitivity to diazoxide. Mutations that result in the loss of KATP channels in pancreatic β-cells have been identified in SUR1 and KIR6.2. These mutations lead to familial hyperinsulinism. Understanding the mutations in SUR and KIR6.x is allowing insight into how these channels respond to nucleotides, sulfonylureas, and potassium channel openers, KCOs.
Title: A VIEW OF SUR/KIR6.X, KATP CHANNELS
Description:
▪ Abstract ATP-sensitive potassium channels, termed KATP channels, link the electrical activity of cell membranes to cellular metabolism.
These channels are heteromultimers of sulfonylurea receptor (SUR) and KIR6.
x subunits associated with a 1:1 stoichiometry as a tetramer (SUR/KIR6.
x)4.
KIR6.
x forms the pores, whereas SUR regulates their activity.
Changes in [ATP]i and [ADP]i gate the channel.
The diversity of KATP channels results from the assembly of SUR and KIR6.
x subtypes.
KIR6.
1-based channels differ from KIR6.
2 channels mainly by their smaller unitary conductance.
SUR1- and SUR2-based channels are distinguished by their differential sensitivity to sulfonylureas, whereas SUR2A-based channels are distinguished from SUR2B channels by their differential sensitivity to diazoxide.
Mutations that result in the loss of KATP channels in pancreatic β-cells have been identified in SUR1 and KIR6.
2.
These mutations lead to familial hyperinsulinism.
Understanding the mutations in SUR and KIR6.
x is allowing insight into how these channels respond to nucleotides, sulfonylureas, and potassium channel openers, KCOs.
Related Results
Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A
Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A
We investigated the mechanism of action of two novel nonsulphonylurea ATP‐sensitive potassium channel (KATP) inhibitors, PNU‐99963 and PNU‐37883A, on four types of cloned KATP chan...
A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane
A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane
Background and purpose:It has been postulated that isoflurane, a volatile anaesthetic, produces vasodilatation through activation of ATP‐sensitive K+ (KATP) channels. However, ther...
Cephalic phase insulin secretion is KATP channel independent
Cephalic phase insulin secretion is KATP channel independent
Glucose-induced insulin secretion from pancreatic β-cells critically depends on the activity of ATP-sensitive K
+
channels (K
...
Exploring the Pathophysiology of ATP-Dependent Potassium Channels in Insulin Resistance
Exploring the Pathophysiology of ATP-Dependent Potassium Channels in Insulin Resistance
Ionic channels are present in eucaryotic plasmatic and intracellular membranes. They coordinate and control several functions. One of the most diverse ionic channels family are the...
Kir6.2-containing K
ATP
channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer’s-related pathology
Kir6.2-containing K
ATP
channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer’s-related pathology
ABSTRACT
Increased neuronal excitability contributes to amyloid-β (Aβ) production and aggregation in the Alzheimer’s disease (AD) brain. Previous...
Diabetes and Insulin Secretion
Diabetes and Insulin Secretion
The ATP-sensitive K+ channel (KATP channel) senses metabolic changes in the pancreatic β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretio...
ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder
ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder
We explored the possibility that ATP-sensitive potassium (KATP) channels exist in urinary bladder smooth muscle, since synthetic openers (e.g., lemakalim) of KATP channels in other...
ASSA13-03-37 Adriamycin Induced Cardiac Dysfunction is Attenuated by Selenium Via Restoring Oxidative Stress Mediated Expression of ATP Sensitive Potassium Channels in Rats
ASSA13-03-37 Adriamycin Induced Cardiac Dysfunction is Attenuated by Selenium Via Restoring Oxidative Stress Mediated Expression of ATP Sensitive Potassium Channels in Rats
Objective
Cardiac toxicity is an important complication of chemotherapy. Selenium (Se) acts as antioxidant agent to protect myocytes from oxidative damage. Lack o...