CFH Y402H and ARMS2 A69S Genes Polymorphism Role in Susceptibility to Rhegmatogenous Retinal Detachment and its Complications

Abstract Background: Rhegmatogenous retinal detachment (RRD) is the most common type of retinal detachment. Purpose of this study is to evaluate the possible association of ARMS2 A69S and CFH Y402H polymorphisms with RRD and its postoperative complications. Materials and Methods: Polymerase chain reaction for DNA replication followed by restriction fragment length polymorphism for enzyme digestion. RRD patients (102 cases) and healthy controls (150 individuals for ARMS2 and 94 individuals for CFH). The two polymorphisms were genotyped by Polymerase Chain Reaction (PCR) – Restriction Fragment Length Polymorphism (RFLP) in a case-control study of 102 RRD patients and 150 controls to evaluate the possible association of ARMS2 A69S and CFH Y402H polymorphism with RRD susceptibility.Results: The genotypes frequencies for ARMS2 A69S and CFH Y402H found to be significantly different between RRD and normal controls (ARMS2 A69S 42.1%vs 32.7%, OR =1.69, p< 0.036 for GT and, CFH Y402H 10.8% vs 6.4%, OR=4.17, p=0.01 for CC genotype and 67.6% vs 40.4%, OR=4.13, p< 0.0001 for CT genotype). The ARMS2 A69S GT genotype showed significant association with postoperative cystoid macular edema (CME) (OR=3.11, P = 0.0039).Conclusions: ARMS2 A69S and CFH Y402H showed significant association with RRD. The ARMS2 A69S GT genotype was also associated with postoperative cystoid macular edema.